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Matija Hedl Selected Research

Crohn Disease (Crohn's Disease)

11/2016A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.
7/2015Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators.
2/2015TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages.
5/2014Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.
3/2013NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation.
7/2011Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages.
1/2011Secretory mediators regulate Nod2-induced tolerance in human macrophages.
12/2007Chronic stimulation of Nod2 mediates tolerance to bacterial products.
8/2004Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations.

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Matija Hedl Research Topics

Disease

9Crohn Disease (Crohn's Disease)
11/2016 - 08/2004
8Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2021 - 11/2012
5Porcine Reproductive and Respiratory Syndrome (PRRS)
10/2021 - 06/2014
2Ulcerative Colitis
11/2016 - 08/2004
1Weight Loss (Weight Reduction)
01/2021
1Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
01/2021
1Bacterial Infections (Bacterial Infection)
01/2017
1Fibrosarcoma
02/2015
1Leprosy (Hansen's Disease)
09/2014
1Infections
12/2012
1Carcinogenesis
11/2012
1Autoimmune Diseases (Autoimmune Disease)
06/2012
1Inflammation (Inflammations)
01/2011

Drug/Important Bio-Agent (IBA)

11CytokinesIBA
10/2021 - 06/2012
9NucleotidesIBA
01/2017 - 01/2011
8Pattern Recognition ReceptorsIBA
10/2021 - 06/2012
5Proteins (Proteins, Gene)FDA Link
01/2021 - 08/2004
2Interleukin-18 (Interleukin 18)IBA
11/2016 - 06/2014
2Peptidoglycan (Murein)IBA
07/2015 - 02/2015
2Interleukin-10 (Interleukin 10)IBA
02/2015 - 11/2012
2Interleukin-1 (Interleukin 1)IBA
06/2014 - 12/2012
2LigandsIBA
05/2014 - 12/2007
1Ligases (Synthetase)IBA
10/2021
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2021
1Dextrans (Dextran)FDA Link
01/2021
1Protein Kinases (Protein Kinase)IBA
01/2021
1Mitogen-Activated Protein KinasesIBA
01/2021
1TNF Receptor-Associated Factor 2 (TRAF2)IBA
01/2021
1Caspase 8 (Caspase-8)IBA
01/2021
1Janus Kinase InhibitorsIBA
11/2016
1Tumor Necrosis Factor Ligand Superfamily Member 15IBA
09/2014
1Interleukin-22 (IL-22)IBA
11/2012
1InflammasomesIBA
11/2012
1Interleukin-8 (Interleukin 8)IBA
08/2004
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2004

Therapy/Procedure

1Therapeutics
11/2016